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  Louse nerve cell structure

New chemistry.

The active ingredient in AVENGE is imidacloprid, belonging to the class of chemical insecticides known as the neonicotinoids. It is the first new molecule in sheep lice control for more than five years. It acts selectively on the central nervous system of lice for rapid control.


New solution.

AVENGE controls lice resistant to other chemical groups:

  • It delivers a completely new mode-of-action for sheep lice control, making it a vital tool for insecticide resistance management.
  • It provides uncompromising lice control while breaking the resistance cycle.
  • The introduction of imidacloprid as a first-in-class active ingredient foreshadows a new era in sheep lice control.

New standard.

TABLE 1: Mode of action and reported first usage of some common sheep lousicides
Chemical class Chemicals

Site of action

Reported for use against sheep lice
in Australia
Neonicotinoids Imidacloprid Nervous system 2009
Spinosyns Spinosad Nervous system 2003ƒ
Macrocyclic lactones (avermectins) Ivermectin Nervous system
and muscles
1995*
Insect growth regulators Diflubenzuron Triflumuron Growth regulation 1993^
Synthetic pyrethroids Cypermethrin Deltamethrin Nervous system 1978Δ
Organophosphates Diazinon Temephos Nervous system 1957

ƒ APVMA PUBCRIS website: http://services.apvma.gov.au/PubcrisWebClient/details.do?view=summary&pcode=56875. Accessed on 13 July 2009.
* Resistance and the control of sheep ectoparasites, Levott, G.L. International Journal for Parasitology, vol. 25, p1355, 1995.
^ Bayer Australia Limited. Data on file.
Δ The efficiency of cypermethrin (NRDC 149) for the treatment and eradication of the sheep louse Damalinia ovis, Hall, C.A., Australian Veterinary Journal, vol. 54, October, p471, 1978.
Recent advances in the control of the ectoparasites of sheep, Brander, G.C., The Australian Veterinary Journal, December, p318, 1957.
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